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Rolapitant hydrochloride

Rolapitant hydrochloride (CAS 858102-79-1) is a potent, selective, orally active NK1 receptor antagonist (Ki=0.66 nM) with long duration and no CYP3A4 interaction. It demonstrates central anti-emetic effects in ferret models, supporting research in chemotherapy-induced nausea and vomiting within neuropharmacology and oncology.

Product Specifications

CAS Number

858102-79-1

Product Name Alternative

NK1, Neurokininreceptor, Neurokinin receptor, Rolapitant HCl, Rolapitant hydrochloride, Rolapitant Hydrochloride

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

98.35% (May vary between batches)

Solubility

DMSO:50 mg/mL (93.12 mM)

Smiles

Cl.C[C@@H] (OC[C@]1 (CC[C@]2 (CCC (=O) N2) CN1) c1ccccc1) c1cc (cc (c1) C (F) (F) F) C (F) (F) F

Molecular Formula

C25H27ClF6N2O2

Molecular Weight

536.94

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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