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Erdafitinib

Erdafitinib (JNJ-42756493) is a potent, pan-FGFR inhibitor targeting FGFR1-4 with low nanomolar IC50 values. It demonstrates pro-apoptotic and antitumor effects, supporting its research use in oncology for both in vitro cellular studies and in vivo xenograft models of FGFR-altered cancers.

Product Specifications

CAS Number

1346242-81-6

Product Name Alternative

Apoptosis, Inhibitor, FGFR4, FGFR, FGFR1, FGFR2, FGFR3, Fibroblast growth factor receptor, Erdafitinib, JNJ 42756493, JNJ42756493, JNJ-42756493, inhibit

Field of Research

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

96.66% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:8.2 mg/mL (18.36 mM) ; Ethanol:15 mg/mL (33.59 mM) ; DMSO:32 mg/mL (71.66 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

COc1cc (OC) cc (c1) N (CCNC (C) C) c1ccc2ncc (nc2c1) -c1cnn (C) c1

Molecular Formula

C25H30N6O2

Molecular Weight

446.54

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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