M62812
This small molecule TLR4 inhibitor suppresses LPS-induced NF-κB activation (IC50 = 2.4 μg/mL in HEK293 cells) and reduces cytokine production in PBMCs and HUVECs. It demonstrates protective effects in a mouse septic shock model, making it a valuable tool for researching sepsis, inflammation, and innate immune signaling pathways.
Product Specifications
CAS Number
613263-00-6
Product Name Alternative
TLR4, M 62812, M62812, M-62812
Field of Research
Immunology & Inflammation
Purity
96.85% (May vary between batches)
Solubility
DMSO:10 mg/mL (30.28 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.03 mM)
Smiles
Cl.Cl.NC1=NSC2=C1C=CC (OC1=C (N) C=CC=C1) =C2
Molecular Formula
C13H13Cl2N3OS
Molecular Weight
330.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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