JKE-1674
JKE-1674 is a bioactive, orally available GPX4 inhibitor and the active metabolite of ML-210. It induces ferroptosis, as demonstrated by its cytotoxicity in LOX-IMVI cells, which is specifically blocked by ferroptosis inhibitors. This compound is a valuable tool for investigating ferroptosis mechanisms in both cellular and animal models.
Product Specifications
CAS Number
2421119-60-8
Product Name Alternative
JKE 1674, JKE1674, JKE-1674, inhibit, ML210, glutathione, Glutathione Peroxidase, Gpx4, Ferroptosis, Inhibitor, peroxidase, rescued
Field of Research
Cell Biology, Metabolism Research
Purity
97.12% (May vary between batches)
Solubility
DMSO:140 mg/mL (310.21 mM)
Smiles
O\N=C (/C[N+] ([O-]) =O) C (=O) N1CCN (CC1) C (c1ccc (Cl) cc1) c1ccc (Cl) cc1
Molecular Formula
C20H20Cl2N4O4
Molecular Weight
451.3
Storage Conditions
-20°C
Notes
For research use only.
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