JKE-1674
JKE-1674 is a bioactive, orally available GPX4 inhibitor and the active metabolite of ML-210. It induces ferroptosis, as demonstrated by its cytotoxicity in LOX-IMVI cells, which is specifically blocked by ferroptosis inhibitors. This compound is a valuable tool for investigating ferroptosis mechanisms in both cellular and animal models.
Product Specifications
CAS Number
2421119-60-8
Product Name Alternative
JKE 1674, JKE1674, JKE-1674, inhibit, ML210, glutathione, Glutathione Peroxidase, Gpx4, Ferroptosis, Inhibitor, peroxidase, rescued
Field of Research
Cell Biology, Metabolism Research
Purity
97.12% (May vary between batches)
Solubility
DMSO:140 mg/mL (310.21 mM)
Smiles
O\N=C (/C[N+] ([O-]) =O) C (=O) N1CCN (CC1) C (c1ccc (Cl) cc1) c1ccc (Cl) cc1
Molecular Formula
C20H20Cl2N4O4
Molecular Weight
451.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV784754 1.0 µg DNA
RPS27P9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details 
GTR15285783 1 Vial
Lentiviral mouse Skint7 shRNA (UAS) - Lentiviral mouse Skint7 shRNA (UAS, iRFP) (100)
Sign In for Pricing
View Details 
MBS6388578-01 0.1 mL
PCCB (Propionyl-CoA Carboxylase beta Chain, Mitochondrial, PCCase Subunit beta, Propanoyl-CoA:Carbon Dioxide Ligase Subunit beta, DKFZp451E113) (MaxLight 750)
Sign In for Pricing
View Details