Polygalasaponin F
Polygalasaponin F is a research compound with demonstrated anti-neuroinflammatory properties, inhibiting LPS-induced TNF-α, NO, and iNOS via NF-κB. It protects neuronal PC12 cells from microglial-mediated cytotoxicity in vitro and enhances synaptic plasticity in the rat hippocampus in vivo through NMDAR/CaMKII/ERK/CREB signaling pathways.
Product Specifications
CAS Number
882664-74-6
Product Name Alternative
Akt, Inhibitor, inhibit, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NFkB, NF-kB, Polygalasaponin F, Phosphoinositide 3-kinase, PI3K, TLR, PKB, Toll-like Receptor (TLR), Protein kinase B
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:60 mg/mL (54.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.83 mM)
Smiles
C[C@@H]1O[C@@H] (O[C@@H]2[C@@H] (O) [C@H] (O) [C@@H] (CO) O[C@H]2OC (=O) [C@]23CCC (C) (C) C[C@H]2C2=CC[C@@H]4[C@@]5 (C) C[C@H] (O) [C@H] (O[C@@H]6O[C@H] (CO) [C@@H] (O) [C@H] (O) [C@H]6O) [C@@] (C) (CO) [C@@H]5CC[C@@]4 (C) [C@]2 (C) CC3) [C@H] (O) [C@H] (O) [C@H]1O[C@@H]1OC[C@@H] (O) [C@H] (O) [C@H]1O
Molecular Formula
C53H86O23
Molecular Weight
1091.24
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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