GSK717
GSK717 is a potent, selective NOD2 inhibitor that disrupts its synergistic signaling with TLR2 while sparing NOD1, TNFR1, and direct TLR2 pathways. This tool compound is valuable for in vitro and in vivo research investigating NOD2's role in inflammatory and autoimmune diseases.
Product Specifications
CAS Number
1595278-21-9
Product Name Alternative
Cytokines, inhibit, immune, IL-8, ILReceptor, NOD2, NOD2-TLR2, NOD-like Receptor (NLR), GSK 717, GSK717, GSK-717, Inhibitor, IL Receptor, MDP-stimulated, pro-inflammatory, responses, synergy
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
97.34% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.05 mM) ; DMSO:250 mg/mL (552.43 mM)
Smiles
CN (CCc1nc2ccccc2n1CC (=O) Nc1ccc2CCCc2c1) C (=O) c1ccccc1
Molecular Formula
C28H28N4O2
Molecular Weight
452.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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