AKN-028
AKN-028 is a potent and orally bioavailable small molecule inhibitor of FLT3 tyrosine kinase, demonstrating an IC50 of 6 nM. It effectively suppresses FLT3 autophosphorylation in a dose-dependent manner and is utilized in preclinical research for investigating acute myeloid leukemia (AML) in both cellular and animal models.
Product Specifications
CAS Number
1175017-90-9
Product Name Alternative
Fms like tyrosine kinase 3, FLT3 autophosphorylation, FLT3, inhibit, Inhibitor, CD135, Cluster of differentiation antigen 135, cytotoxic, Apoptosis, AML cell lines, Caspase, AKN 028, AKN028, AKN-028, acute myeloid leukemia
Field of Research
Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction
Purity
97.30% (May vary between batches)
Solubility
DMSO:20 mg/mL (66.15 mM)
Smiles
N (C=1N=C (C=NC1N) C=2C=CN=CC2) C=3C=C4C (=CC3) NC=C4
Molecular Formula
C17H14N6
Molecular Weight
302.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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