Thailanstatin A
Thailanstatin A is an ultra-potent eukaryotic RNA splicing inhibitor that non-covalently targets the SF3b subunit, exhibiting low-nanomolar cytotoxicity against various cancer cell lines. It serves as a potent payload for antibody-drug conjugates (ADCs), such as when conjugated to trastuzumab, and is used in cancer research for both in vitro and in vivo studies of spliceosome inhibition.
Product Specifications
CAS Number
1426953-21-0
Product Name Alternative
Antiproliferative, ADC, ADCCytotoxin, ADC Cytotoxin, ADC Payload, inhibit, Inhibitor, linker, natural, RNA, spliceosome, subunit, SF3b, Thailanstatin A
Purity
93.69% (May vary between batches)
Solubility
DMSO:245 mg/mL (457.41 mM)
Smiles
C[C@H] (OC (C) =O) \C=C/C (=O) N[C@@H]1C[C@H] (C) [C@H] (C\C=C (/C) \C=C\[C@H]2O[C@H] (CC (O) =O) C[C@@]3 (CO3) [C@@H]2O) O[C@@H]1C
Molecular Formula
C28H41NO9
Molecular Weight
535.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
132459-APC 100 µL
RECQL4 (RECQ4, ATP-dependent DNA Helicase Q4, DNA Helicase, RecQ-like Type 4, RTS, RecQ Protein-like 4) (APC)
Sign In for Pricing
View Details