Polyphyllin I

Polyphyllin D is a bioactive steroidal saponin with potent anticancer activity, inducing mitochondrial-mediated apoptosis and overcoming drug resistance in vitro. Its mechanisms include Bcl-2 downregulation, Bax upregulation, and caspase-3 activation, alongside noted anti-angiogenic and erythrocyte toxicity effects, supporting its research in oncology and hematology studies.

Product Specifications

CAS Number

50773-41-6

Product Name Alternative

Mammalian target of Rapamycin, Inhibitor, inhibit, JNK, mTOR, Akt, apoptosis, Apoptosis, Autophagy, Protein kinase B, Polyphyllin I, PDK-1, PDK1, PKB

Field of Research

Cell Biology, Signal Transduction

Purity

98.00% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.17 mM) ; DMSO:250 mg/mL (292.39 mM)

Smiles

[H][C@]12C[C@@]3 ([H]) [C@]4 ([H]) CC=C5C[C@H] (CC[C@]5 (C) [C@@]4 ([H]) CC[C@]3 (C) [C@@]1 ([H]) [C@H] (C) [C@@]1 (CC[C@@H] (C) CO1) O2) O[C@]1 ([H]) O[C@H] (CO) [C@@H] (O[C@]2 ([H]) O[C@@H] (CO) [C@H] (O) [C@H]2O) [C@H] (O) [C@H]1O[C@]1 ([H]) O[C@@H] (C) [C@H] (O) [C@@H] (O) [C@H]1O