Arglabin

Arglabin ((+) -Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities[1]. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene[2].

Product Specifications

CAS Number

[84692-91-1]

Product Name Alternative

(+) -Arglabin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Farnesyl Transferase; NOD-like Receptor (NLR)

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Arglabin.html

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@]1(CC[C@](C2=C)([H])[C@@](OC2=O)([H])[C@@]3([H])C(C)=CC4)[C@]34O1

Molecular Formula

C15H18O3

Molecular Weight

246.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Abderrazak A, et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation. 2015;131 (12) :1061-1070.|[2]Lone SH, et al. Arglabin: From isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180-198.