CZC-54252 hydrochloride
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor, demonstrating IC50 values of 1.85 nM (wild-type) and 1.28 nM (G2019S mutant) . It exhibits neuroprotective properties in cellular models, attenuating G2019S LRRK2-induced neuronal injury with an EC50 of 1 nM, making it a valuable research tool for Parkinson's disease studies.
Product Specifications
CAS Number
1784253-05-9
Product Name Alternative
CZC 54252, CZC 54252 hydrochloride, CZC 54252 Hydrochloride, CZC54252, CZC-54252, CZC54252 hydrochloride, CZC54252 Hydrochloride, CZC-54252 Hydrochloride, inhibit, LRRK2-G2019S, LRRK2, neuronal, neuroprotective, G2019S LRRK2, Leucine-rich repeat kinase 2, injury, Inhibitor
Field of Research
Cell Biology
Purity
98.21% (May vary between batches)
Solubility
DMSO:30 mg/mL (55.41 mM)
Smiles
Cl.COc1cc (ccc1Nc1ncc (Cl) c (Nc2ccccc2NS (C) (=O) =O) n1) N1CCOCC1
Molecular Formula
C22H26Cl2N6O4S
Molecular Weight
541.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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