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SMI-16a

SMI-16a is a potent and selective ATP-competitive inhibitor of Pim-1 and Pim-2 kinases, with IC50 values of 150 nM and 20 nM, respectively. It demonstrates high selectivity, showing minimal activity against 57 other kinases. This compound is a valuable chemical probe for investigating Pim kinase function in cancer research and cellular signaling studies both in vitro and in vivo.

Product Specifications

CAS Number

587852-28-6

Product Name Alternative

Inhibit, Inhibitor, SMI16a, SMI-16a, SMI 16a, Pim2, PIM1/2 Kinase Inhibitor VI, Pim, Pim kinases, Pim1

Field of Research

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Purity

97.06% (May vary between batches)

Solubility

DMSO:150 mg/mL (569.67 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.19 mM)

Smiles

CCCOc1ccc (\C=C2\SC (=O) NC2=O) cc1

Molecular Formula

C13H13NO3S

Molecular Weight

263.31

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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