EB-42486
EB-42486 is a potent and selective small molecule inhibitor targeting the G2019S-LRRK2 kinase mutation, exhibiting sub-nanomolar inhibitory activity (IC50 < 0.2 nM) . This compound is a valuable research tool for investigating LRRK2-linked Parkinson's disease pathology in both cellular and animal models.
Product Specifications
CAS Number
2390475-81-5
Product Name Alternative
EB42486, EB-42486, EB 42486, G2019S LRRK2, Inhibitor, Leucine-rich repeat kinase 2, inhibit, LRRK2
Field of Research
Cell Biology
Purity
98.06% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.06 mM) ; DMSO:245 mg/mL (591.13 mM)
Smiles
CN1c2nnnn2C (C) (C) C (C (=O) Nc2ccc3[nH]nc (-c4ccccc4) c3c2) =C1C
Molecular Formula
C22H22N8O
Molecular Weight
414.46
Storage Conditions
-20°C
Notes
For research use only.
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