306-O12B-3
306-O12B-3 is an ionizable lipidoid with cationic properties, commonly used in lipid nanoparticle (LNP) formulations for antisense oligonucleotide (ASO) delivery. When administered intravenously in mice, LNPs incorporating 306-O12B-3 exhibit liver-specific accumulation. Studies show that ASO-loaded LNPs containing 306-O12B-3 effectively silence hepatic PCSK9 expression by targeting the proprotein convertase subtilisin/kexin type 9 gene. Additionally, when combined with the cationic lipidoid NT1-O14B (Item No. 37095), these LNPs can deliver tau-targeting ASOs to the brain, reducing tau protein levels in mice.
Product Specifications
CAS Number
2982842-90-8
Purity
>95%
Smiles
S (CCCCCCCC) SCCOC (CCN (CCC (=O) OCCSSCCCCCCCC) CCCN (C) CCCNCCC (=O) OCCSSCCCCCCCC) =O
Molecular Formula
C46H91N3O6S6
Molecular Weight
974.62
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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