Kobe0065
Kobe0065 is a novel small-molecule inhibitor of the Ras-Raf interaction, developed through structure-based drug design. It competitively inhibits H-Ras·GTP binding to c-Raf-1 RBD with a Ki of 46 ± 13 μM, making it a useful tool for in vitro studies of MAPK/ERK pathway signaling and oncogenic Ras function.
Product Specifications
CAS Number
436133-68-5
Product Name Alternative
Inhibitor, Kobe 0065, Kobe0065, Kobe-0065, inhibit, Apoptosis, Ras-Raf, Ras
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:20 mg/mL (44.47 mM) ; Ethanol:4.5 mg/mL (10 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.45 mM)
Smiles
Cc1ccc (NC (=S) NNc2c (cc (cc2[N+] ([O-]) =O) C (F) (F) F) [N+] ([O-]) =O) cc1Cl
Molecular Formula
C15H11ClF3N5O4S
Molecular Weight
449.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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