SB-431542
SB-431542 is a potent and selective inhibitor of the TGF-β type I receptor ALK5 (IC50=94 nM), with additional activity against ALK4 and ALK7. It is widely used in research to study TGF-β signaling pathways, including in vitro stem cell differentiation and investigations into fibrosis and cancer biology.
Product Specifications
CAS Number
301836-41-9
Product Name Alternative
ALK5, ALK4, ALK7, Inhibitor, inhibit, TGFb, TGF-b/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, TGFβ, TGF-β/Smad, TGF-β Receptor, Smad, SB 431542, SB431542, SB-431542, Transforming growth factor beta receptors
Field of Research
Immunology & Inflammation, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
ALK4,5 and 7 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml) .
Smiles
NC (=O) c1ccc (cc1) -c1nc (c ([nH]1) -c1ccccn1) -c1ccc2OCOc2c1
Molecular Formula
C22H16N4O3
Molecular Weight
384.40
Storage Conditions
RT
Notes
For research use only.
Other Product Names
4-[4- (1,3-Benzodioxol-5-yl) -5- (2-pyridinyl) -1H-imidazol-2-yl]benzamide
Available Sizes
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