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Afatinib Dimaleate

Afatinib Dimaleate is an orally active, irreversible inhibitor of the ErbB (EGFR) family of receptor tyrosine kinases. This small molecule is used in research to study oncogenic signaling and has demonstrated antitumor activity in both cellular assays and animal models of non-small cell lung cancer and other solid tumors.

Product Specifications

CAS Number

850140-73-7

Product Name Alternative

Inhibit, NCI-H1975, NIH-3T3 cells, NSCLC, orally active, lung cancer, HER2, HER1, Inhibitor, HKESC-1, HKESC-2, H1666, H3255, EGFR (L858R/T790M), EGFR (L858R), EGFR (wt), EC-1, EGFR, ErbB-1, Epidermal growth factor receptor, ESCC, Autophagy, Apoptosis, anticancer, BIBW 2992, BIBW 2992MA2, BIBW2992, BIBW-2992, A431, Afatinib Dimaleate, Afatinib, Afatinib (BIBW2992), Afatinib (BIBW2992) Dimaleate, Akt, c-Met/HGFR, SLMT-1, Protein kinase B, PKB, p38 MAPK

Field of Research

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.11% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:252 mg/mL (350.94 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

OC (=O) \C=C/C (O) =O.OC (=O) \C=C/C (O) =O.CN (C) C\C=C\C (=O) Nc1cc2c (Nc3ccc (F) c (Cl) c3) ncnc2cc1O[C@H]1CCOC1

Molecular Formula

C32H33ClFN5O11

Molecular Weight

718.08

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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