APX-115 free base
APX-115 free base is a potent, orally bioavailable pan-NOX inhibitor, with Kis in the sub-micromolar range for Nox1, Nox2, and Nox4 isoforms. It has demonstrated efficacy in preventing kidney injury in animal models and is a valuable research tool for studying oxidative stress in diseases like diabetic nephropathy and fibrosis.
Product Specifications
CAS Number
1270084-92-8
Product Name Alternative
Resistance, plasma, inhibit, Inhibitor, kidney, Nox1, Nox2, Nox3, Nox4, NOX, NADPHoxidase, NADPH Oxidase, injury, insulin, Ewha 18278, Ewha18278, Ewha-18278, Ewha-18278 free base, APX115, APX-115, APX115 free base, APX-115 free base, APX 115, APX 115 free base, albumin, creatinine
Field of Research
Immunology & Inflammation, Metabolism Research
Purity
98.39% (May vary between batches)
Solubility
DMSO:245 mg/mL (877.07 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (17.9 mM)
Smiles
CCCc1c (O) n (nc1-c1ccccc1) -c1ccccn1
Molecular Formula
C17H17N3O
Molecular Weight
279.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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