Farudodstat
Farudodstat (ASLAN003) is a potent, orally bioavailable inhibitor of human dihydroorotate dehydrogenase (DHODH) with demonstrated antitumor activity. It shows promise as a first-in-class therapeutic candidate for acute myeloid leukemia (AML), supported by evidence from both in vitro cellular assays and in vivo animal models.
Product Specifications
CAS Number
1035688-66-4
Product Name Alternative
DHODH, Dihydroorotate Dehydrogenase, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, acute, ASLAN 003, ASLAN003, ASLAN-003, AP-1, Apoptosis, AML, caspase-8, caspase-7, caspase-3, MOLM-14, OPP, orally, KG-1, inhibit, myeloid, Inhibitor, leukemia, EIF4B, Farudodstat, RPL6, RNASynthesis, RNA Synthesis, synthesis, protein, THP-1
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Purity
98.03% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.23 mM) ; DMSO:250 mg/mL (701.62 mM)
Smiles
COc1cccc (c1) -c1cc (F) c (Nc2ncccc2C (O) =O) c (F) c1
Molecular Formula
C19H14F2N2O3
Molecular Weight
356.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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