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(E/Z) -BCI

(E/E) -BCI (NSC-150117) is a DUSP6 inhibitor with anti-inflammatory activity. It suppresses LPS-induced inflammation and oxidative stress in macrophages by inhibiting the NF-κB pathway and activating Nrf2 signaling. This compound is a useful research tool for studying inflammation, redox biology, and macrophage function in vitro.

Product Specifications

CAS Number

15982-84-0

Product Name Alternative

Anti-inflammatory, Apoptosis, (E/Z) BCI, (E/Z) BCI, (E/Z) -BCI, DUSP6, ERK, death, gastric cancer, Inhibitor, inhibit, LPS, NSC150117, NSC-150117, NSC 150117, Nrf2, NF-κB, ROS, Phosphatase

Field of Research

Cell Biology, Metabolism Research

Purity

98.55% (May vary between batches)

Solubility

Ethanol:20 mg/mL (63.01 mM) ; DMSO:50 mg/mL (157.52 mM)

Smiles

O=C1C (=Cc2ccccc2) C (NC2CCCCC2) c2ccccc12

Molecular Formula

C22H23NO

Molecular Weight

317.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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