NMS-859
NMS-859 is a potent, covalent inhibitor of VCP/p97, demonstrating consistent cellular activity with IC50 values of approximately 0.37 μM across physiological ATP concentrations. This small molecule is a valuable research tool for investigating VCP-related pathways in cancer, neurodegenerative diseases, and in vitro protein homeostasis studies.
Product Specifications
CAS Number
1449236-96-7
Product Name Alternative
Valosin-containing protein (VCP) /p97, ZINC 169324353, ZINC169324353, ZINC-169324353, NMS 859, NMS859, NMS-859
Field of Research
Neuroscience, Protein Biochemistry
Purity
97.36% (May vary between batches)
Solubility
DMSO:3.5 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.86 mM)
Smiles
ClCC (=O) OC1=CC=CC (NC2=NS (=O) (=O) C3=C2C=CC=C3) =C1
Molecular Formula
C15H12ClN3O3S
Molecular Weight
349.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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