RIPK1-IN-7
RIPK1-IN-7 is a highly potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. It demonstrates significant antimetastatic efficacy in vivo, as shown in a B16 melanoma lung metastasis model, making it a valuable tool for researching necroptosis and inflammatory diseases.
Product Specifications
CAS Number
2300982-44-7
Product Name Alternative
Axl, Flt4, HRI, Mer, Inhibitor, inhibit, Receptor-interacting protein kinases, RIPK, RIP kinase, RIPK1, RIPkinase, RIPK1 IN 7, RIPK1IN7, RIPK-1-IN-7, RIPK1-IN-7, TrkA, TrkC, TrkB
Field of Research
Cell Biology, Signal Transduction
Purity
96.29% (May vary between batches)
Solubility
DMSO:60 mg/mL (124.62 mM) ; H2O:0.1 mg/mL (0.21 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.15 mM)
Smiles
CCn1cc (-c2ccc3N (CCc3c2) C (=O) Cc2cccc (OC (F) (F) F) c2) c2c (N) ncnc12
Molecular Formula
C25H22F3N5O2
Molecular Weight
481.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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