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RIPK1-IN-7

RIPK1-IN-7 is a highly potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. It demonstrates significant antimetastatic efficacy in vivo, as shown in a B16 melanoma lung metastasis model, making it a valuable tool for researching necroptosis and inflammatory diseases.

Product Specifications

CAS Number

2300982-44-7

Product Name Alternative

Axl, Flt4, HRI, Mer, Inhibitor, inhibit, Receptor-interacting protein kinases, RIPK, RIP kinase, RIPK1, RIPkinase, RIPK1 IN 7, RIPK1IN7, RIPK-1-IN-7, RIPK1-IN-7, TrkA, TrkC, TrkB

Field of Research

Cell Biology, Signal Transduction

Purity

96.29% (May vary between batches)

Solubility

DMSO:60 mg/mL (124.62 mM) ; H2O:0.1 mg/mL (0.21 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.15 mM)

Smiles

CCn1cc (-c2ccc3N (CCc3c2) C (=O) Cc2cccc (OC (F) (F) F) c2) c2c (N) ncnc12

Molecular Formula

C25H22F3N5O2

Molecular Weight

481.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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