Edicotinib
Edicotinib (JNJ-527) is a brain-penetrant, oral CSF-1R inhibitor with selectivity over KIT and FLT3. It suppresses microglial proliferation and neurodegeneration, making it a valuable research tool for studying Alzheimer's disease and rheumatoid arthritis in both in vitro and in vivo models.
Product Specifications
CAS Number
1142363-52-7
Product Name Alternative
Inhibitor, Edicotinib, expansion, FLT3, neurodegeneration, microglial, inhibit, kit, JNJ 40346527, JNJ 527, JNJ40346527, JNJ-40346527, JNJ527, JNJ-527, colony stimulating factor 1 receptor, cKit, c-Fms, cFms, CSF-1R, CSF1R, CSF-1 receptor, alzheimer's disease, arthritis, rheumatoid
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.58% (May vary between batches)
Solubility
DMSO:2.31 mg/mL (5 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.17 mM)
Smiles
CC1 (C) CCC (=CC1) c1nc (ccc1NC (=O) c1ncc ([nH]1) C#N) C1CC (C) (C) OC (C) (C) C1
Molecular Formula
C27H35N5O2
Molecular Weight
461.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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