GSK2334470
GSK2334470 is a potent and selective small molecule inhibitor of PDK1, demonstrating an IC50 of approximately 10 nM in biochemical assays with minimal activity against related AGC kinases. This tool compound is used in vitro to investigate PI3K/PDK1 signaling pathways in cancer research and has been utilized in vivo to study metabolic regulation.
Product Specifications
CAS Number
1227911-45-6
Product Name Alternative
GSK-470
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Selective PDK1 (PDPK1) inhibitor
Form
Powder
Solubility
Soluble in DMSO (40 mg/ml)
Smiles
CNc1nc (cc (n1) -c1ccc2c (N) n[nH]c2c1) N1C[C@H] (CC[C@H]1C) C (=O) NC1CCCCC1
Molecular Formula
C25H34N8O
Molecular Weight
462.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(3S,6R) -1-[6- (3-Amino-1H-indazol-6-yl) -2- (methylamino) -4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
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