ABC99
ABC99 is a potent and selective irreversible inhibitor of the NOTUM carboxylesterase, a key enzyme that deacylates Wnt proteins. With an IC50 of 13 nM and excellent selectivity over other serine hydrolases, it is a valuable chemical probe for investigating Wnt signaling pathways in both cellular and animal models of development and disease.
Product Specifications
CAS Number
2331255-53-7
Product Name Alternative
ABC-99, ABC99, ABC 99, bcatenin, beta-catenin, betacatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin, βcatenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
98.65% (May vary between batches)
Solubility
DMSO:20 mg/mL (43.78 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (4.38 mM)
Smiles
Clc1ccc (CN2CCN3C (C2) C (=O) N (OC (=O) N2CCOc4ccccc24) C3=O) cc1
Molecular Formula
C22H21ClN4O5
Molecular Weight
456.88
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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