Ribociclib succinate
Ribociclib succinate (LEE011 succinate) is a potent and selective inhibitor of CDK4 and CDK6, with IC50 values of 10 nM and 39 nM, respectively, while showing minimal activity against CDK1. It is widely used in cancer research, particularly for studying cell cycle arrest in breast cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
1374639-75-4
Product Name Alternative
Inhibitor, LEE 011, LEE011 Succinate, LEE011 succinate, LEE-011 Succinate, LEE 011 Succinate, LEE011, LEE-011, inhibit, CDK6, CDK4, CDK, Cyclin dependent kinase, Ribociclib, Ribociclib succinate, Ribociclib Succinate
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.57% (May vary between batches)
Solubility
DMSO:9 mg/mL (16.29 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (0.9 mM)
Smiles
OC (=O) CCC (O) =O.CN (C) C (=O) c1cc2cnc (Nc3ccc (cn3) N3CCNCC3) nc2n1C1CCCC1
Molecular Formula
C27H36N8O5
Molecular Weight
552.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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