Lofepramine
Lofepramine is a tricyclic antidepressant prodrug metabolized to desipramine. It potently inhibits norepinephrine and serotonin reuptake (Kd 5.4 nM and 70 nM, respectively) with weak receptor antagonism, making it a useful research tool for studying neurotransmitter transport and depression models in vitro and in vivo.
Product Specifications
CAS Number
23047-25-8
Product Name Alternative
Amplit, 5HTReceptor, 5HT Receptor, norepinephrine reuptake, Lofepramine, inhibit, Lopramine, Inhibitor, Leo 640, Gamanil, serotonin reuptake
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
96.96% (May vary between batches)
Solubility
DMSO:48 mg/mL (114.57 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (4.77 mM)
Smiles
C (CCN (CC (=O) C1=CC=C (Cl) C=C1) C) N2C=3C (CCC=4C2=CC=CC4) =CC=CC3
Molecular Formula
C26H27ClN2O
Molecular Weight
418.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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