Luzindole
Luzindole (N-0774) is a selective melatonin receptor antagonist with a preferential affinity for the MT2 subtype (Ki = 10.2 nM) over MT1 (Ki = 158 nM) . It has demonstrated efficacy in research models, showing inhibitory effects in experimental autoimmune encephalomyelitis (EAE) and exhibiting antidepressant-like activity in preclinical studies.
Product Specifications
CAS Number
117946-91-5
Product Name Alternative
Preferentially, selective, subtype, encephalomyelitis, human MT1, human MT2, Inhibitor, Melatonin Receptor, MelatoninReceptor, Luzindole, inhibit, MT Receptor, MT1 receptor, MT2 receptor, MTReceptor, N 0774, N0774, N-0774, antidepressant-like, anti-immobility, autoimmune
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.53% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.68 mM) ; DMSO:100 mg/mL (342.03 mM)
Smiles
CC (=O) NCCc1c (Cc2ccccc2) [nH]c2ccccc12
Molecular Formula
C19H20N2O
Molecular Weight
292.37
Storage Conditions
-20°C
Notes
For research use only.
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