Belzutifan
Belzutifan (MK-6482) is a potent and selective oral HIF-2α inhibitor with an IC50 of 9 nM, developed for clear cell renal cell carcinoma (ccRCC) research. It demonstrates efficacy in both in vitro assays and in vivo xenograft models, supporting its investigation in oncology and hypoxia-related pathways.
Product Specifications
CAS Number
1672668-24-4
Product Name Alternative
Belzutifan, Inhibitor, inhibit, MK 6482, MK6482, MK-6482, HIF-PH, HIFs, HIF-2α, HIF/HIF Prolyl-Hydroxylase, Hypoxia-inducible factors, PT 2977, PT2977, PT-2977
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research
Purity
99.34% (May vary between batches)
Solubility
DMSO:50.5 mg/mL (131.74 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM)
Smiles
CS (=O) (=O) c1ccc (Oc2cc (F) cc (c2) C#N) c2[C@@H] (F) [C@@H] (F) [C@@H] (O) c12
Molecular Formula
C17H12F3NO4S
Molecular Weight
383.34
Storage Conditions
-20°C
Notes
For research use only.
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