Ro 08-2750
Ro 08-2750 is a reversible, non-peptide inhibitor of nerve growth factor (NGF) with an IC50 of ~1 μM, selectively blocking its binding to p75NTR over TrkA. It also inhibits MSI RNA-binding activity (IC50=2.7 μM) . This small molecule is used in vitro to study neurotrophin signaling and oncogenic RNA-binding proteins in cancer and neuroscience research.
Product Specifications
CAS Number
37854-59-4
Product Name Alternative
Apoptosis, AML, leukemia, Inhibitor, growth, factor, MUSASHI, MSI, inhibit, p75NTR, NGF, Nerve, RNA-binding, Ro 08 2750, Ro 082750, Ro 08-2750, TRKA
Field of Research
Cell Biology
Purity
95.06% (May vary between batches)
Solubility
DMSO:3.5 mg/mL (12.95 mM)
Smiles
Cc1cc2nc3c (nc (=O) [nH]c3=O) n (C) c2cc1C=O
Molecular Formula
C13H10N4O3
Molecular Weight
270.24
Storage Conditions
-20°C
Notes
For research use only.
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