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JW 67

JW 67 is a small molecule inhibitor of the canonical Wnt/β-catenin pathway. It acts by rapidly decreasing active β-catenin levels, leading to the downregulation of target genes such as AXIN2, SP5, and NKD1. This inhibitor is a valuable tool for studying Wnt signaling in both cellular assays and in vivo disease models, including cancer and stem cell research.

Product Specifications

CAS Number

442644-28-2

Product Name Alternative

GSK-3b, Inhibitor, JW67, JW-67, JW 67, multiprotein, inhibit, CK1, complex, beta-catenin, betacatenin, bcatenin, AXIN, APC, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin

Field of Research

Signal Transduction, Stem Cell & Developmental Biology

Purity

97.02% (May vary between batches)

Solubility

DMSO:60 mg/mL (152.14 mM) ;10% DMSO+90% Saline:2.5 mg/mL (6.34 mM)

Smiles

O=C1Nc2ccccc2C11OCC2 (CO1) COC1 (OC2) C (=O) Nc2ccccc12

Molecular Formula

C21H18N2O6

Molecular Weight

394.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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