JW 67
JW 67 is a small molecule inhibitor of the canonical Wnt/β-catenin pathway. It acts by rapidly decreasing active β-catenin levels, leading to the downregulation of target genes such as AXIN2, SP5, and NKD1. This inhibitor is a valuable tool for studying Wnt signaling in both cellular assays and in vivo disease models, including cancer and stem cell research.
Product Specifications
CAS Number
442644-28-2
Product Name Alternative
GSK-3b, Inhibitor, JW67, JW-67, JW 67, multiprotein, inhibit, CK1, complex, beta-catenin, betacatenin, bcatenin, AXIN, APC, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
97.02% (May vary between batches)
Solubility
DMSO:60 mg/mL (152.14 mM) ;10% DMSO+90% Saline:2.5 mg/mL (6.34 mM)
Smiles
O=C1Nc2ccccc2C11OCC2 (CO1) COC1 (OC2) C (=O) Nc2ccccc12
Molecular Formula
C21H18N2O6
Molecular Weight
394.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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