Galunisertib
Galunisertib (LY2157299) is a selective TGF-β receptor type I inhibitor (IC50=56 nM) with demonstrated antitumor activity. It is widely used in oncology research, particularly in studies exploring its mechanism in vitro and its efficacy in combination with immune checkpoint inhibitors like anti-PD-1 antibodies in vivo tumor models.
Product Specifications
CAS Number
700874-72-2
Product Name Alternative
LY2157299
Field of Research
Immunology & Inflammation, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
TGFß receptor 1 inhibitor / Cancer immunotherapeutic
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
Cc1cccc (n1) -c1nn2CCCc2c1-c1ccnc2ccc (cc12) C (N) =O
Molecular Formula
C22H19N5O
Molecular Weight
369.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[2- (6-Methylpyridin-2-yl) -5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
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