Macitentan
Macitentan (ACT-064992) is a dual endothelin receptor antagonist employed in pulmonary arterial hypertension (PAH) research. It is widely used in both in vitro binding assays and in vivo animal models to study endothelin signaling pathways and evaluate potential therapeutic interventions.
Product Specifications
CAS Number
441798-33-0
Product Name Alternative
Arterial, Apoptosis, ACT064992, ACT-064992, ACT 064992, Inhibitor, hypertension, idiopathic, endothelin, Endothelin Receptor, EndothelinReceptor, ET-B, ETB, ET-A, ETA, fibrosis, inhibit, non-peptide, orally, Macitentan, pulmonary
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:93 mg/mL (158.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.61 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
N (S (NCCC) (=O) =O) C=1C (=C (OCCOC=2N=CC (Br) =CN2) N=CN1) C3=CC=C (Br) C=C3
Molecular Formula
C19H20Br2N6O4S
Molecular Weight
588.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6195677-01 0.1 mL
GABARAP (GABA(A) Receptor-Associated Protein, FLJ25768, MGC120154, MGC120155, MM46) (MaxLight 405)
Sign In for Pricing
View Details MBS6195677-02 5x 0.1 mL
GABARAP (GABA(A) Receptor-Associated Protein, FLJ25768, MGC120154, MGC120155, MM46) (MaxLight 405)
Sign In for Pricing
View Details 
MBS6184508-01 0.1 mL
ATOX1 (ATX1 Antioxidant Protein 1 Homolog (yeast), ATX1, HAH1, MGC138453, MGC138455) (PE)
Sign In for Pricing
View Details MBS6184508-02 5x 0.1 mL
ATOX1 (ATX1 Antioxidant Protein 1 Homolog (yeast), ATX1, HAH1, MGC138453, MGC138455) (PE)
Sign In for Pricing
View Details