GSK126
GSK126 (GSK2816126A) is a potent and selective EZH2 methyltransferase inhibitor (IC50=9.9 nM) . It demonstrates antitumor activity in research by inhibiting the proliferation of cancer cells and suppressing angiogenesis, as shown in both in vitro and in vivo studies.
Product Specifications
CAS Number
1346574-57-9
Product Name Alternative
GSK-2816126
Field of Research
Cancer Biology, Epigenetics & Chromatin, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
EZH2 Histone methyltransferase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 16 mg/ml)
Smiles
CC[C@H] (C) n1cc (C) c2c (cc (cc12) -c1ccc (nc1) N1CCNCC1) C (=O) NCc1c (C) cc (C) [nH]c1=O
Molecular Formula
C31H38N6O2
Molecular Weight
526.7
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[ (1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl) methyl]-3-methyl-1-[ (1S) -1-methylpropyl]-6-[6- (1-piperazinyl) -3-pyridinyl]-1H-indole-4-carboxamide
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