X-376
Ensartinib (X-376) is a potent, orally bioavailable ALK inhibitor that targets ALK fusions and mutations, disrupting oncogenic signaling and suppressing tumor growth in ALK-driven cancers. It is widely used in preclinical research, demonstrating efficacy in both in vitro cellular assays and in vivo xenograft models of non-small cell lung cancer (NSCLC) .
Product Specifications
CAS Number
1365267-27-1
Product Name Alternative
Cluster of differentiation 246, CD246, cMet/HGFR, c-Met, cMet, c-Met/HGFR, ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), inhibit, MET, Inhibitor, HGFR, Ensartinib, X-396, X396, X-376, X376, X 376, X 396
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.87% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.65 mM) ; DMSO:37 mg/mL (67.59 mM)
Smiles
C[C@@H] (Oc1cc (nnc1N) C (=O) Nc1ccc (cc1) C (=O) N1CCN (C) CC1) c1c (Cl) ccc (F) c1Cl
Molecular Formula
C25H25Cl2FN6O3
Molecular Weight
547.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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