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Compound 401

Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a potent and selective small molecule inhibitor of DNA-PK with an IC50 of 0.28 μM, which additionally inhibits mTOR while sparing PI3K. It is a valuable chemical probe for studying DNA damage response and repair pathways in both cellular and animal models of cancer research.

Product Specifications

CAS Number

168425-64-7

Product Name Alternative

Inhibitor, inhibit, 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one, DNA-dependent protein kinase, DNA-PK, DNAPK, Compound401, Compound-401, Compound 401

Field of Research

Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

99.19% (May vary between batches)

Solubility

DMSO:5.45 mg/mL (19.37 mM)

Smiles

O=c1cc (nc2c3ccccc3ccn12) N1CCOCC1

Molecular Formula

C16H15N3O2

Molecular Weight

281.31

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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