Cobicistat
Cobicistat (GS-9350) is a pharmacoenhancer used in HIV research that potently inhibits cytochrome P450 3A (CYP3A) enzymes. This inhibition boosts systemic exposure of co-administered antiretroviral drugs like protease inhibitors, a mechanism validated in both in vitro metabolic studies and in vivo pharmacokinetic research for combination therapy.
Product Specifications
CAS Number
1004316-88-4
Product Name Alternative
CYP3A, CYPs, Cytochrome P450, Cobicistat, antiviral, GS 9350, GS9350, GS-9350, Human immunodeficiency virus, HIV, HIV Protease, HIV-1, HIVProtease, inhibit, Inhibitor, Tybost
Field of Research
Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
97.36% (May vary between batches)
Solubility
Ethanol:93 mg/mL (119.84 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.25 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:93 mg/mL (119.84 mM)
Smiles
CC (C) c1nc (CN (C) C (=O) N[C@@H] (CCN2CCOCC2) C (=O) N[C@H] (CC[C@H] (Cc2ccccc2) NC (=O) OCc2cncs2) Cc2ccccc2) cs1
Molecular Formula
C40H53N7O5S2
Molecular Weight
776.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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