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SNX2112

SNX2112 (PF-04928473) is a potent, orally bioavailable small molecule inhibitor of Hsp90, exhibiting a dissociation constant (Kd) of 16 nM. It is utilized in cancer research to study oncogenic client protein degradation and has demonstrated antitumor activity in both cellular assays and animal xenograft models.

Product Specifications

CAS Number

908112-43-6

Product Name Alternative

HSP90α, HSP90β, SNX 2112, SNX2112, SNX-2112, PF04928473, PF-04928473, PF 04928473

Field of Research

Cell Biology, Metabolism Research, Signal Transduction

Purity

98.75% (May vary between batches)

Solubility

Ethanol:1 mg/mL (2.15 mM) ; DMSO:86 mg/mL (185.15 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

CC1 (C) Cc2c (c (nn2-c2ccc (C (N) =O) c (NC3CCC (O) CC3) c2) C (F) (F) F) C (=O) C1

Molecular Formula

C23H27F3N4O3

Molecular Weight

464.48

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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