SNX2112
SNX2112 (PF-04928473) is a potent, orally bioavailable small molecule inhibitor of Hsp90, exhibiting a dissociation constant (Kd) of 16 nM. It is utilized in cancer research to study oncogenic client protein degradation and has demonstrated antitumor activity in both cellular assays and animal xenograft models.
Product Specifications
CAS Number
908112-43-6
Product Name Alternative
HSP90α, HSP90β, SNX 2112, SNX2112, SNX-2112, PF04928473, PF-04928473, PF 04928473
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.75% (May vary between batches)
Solubility
Ethanol:1 mg/mL (2.15 mM) ; DMSO:86 mg/mL (185.15 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CC1 (C) Cc2c (c (nn2-c2ccc (C (N) =O) c (NC3CCC (O) CC3) c2) C (F) (F) F) C (=O) C1
Molecular Formula
C23H27F3N4O3
Molecular Weight
464.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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