What is the catalog number for OSI-027?

The catalog number for OSI-027 is orb1300874.

What sizes are available for OSI-027?

OSI-027 is available in the following size(s): 1 mg, 2 mg, 5 mg, 1 ml x 10 mM (in DMSO), 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does OSI-027 come in?

OSI-027 is available in 8 different pack sizes.

OSI-027 is currently made to order / not held in immediate stock. Contact us for lead time.

OSI-027

OSI-027 (ASP4786) is a potent and selective dual mTORC1/mTORC2 inhibitor with IC50 values of 22 nM and 65 nM, respectively, demonstrating over 100-fold selectivity against related PI3K isoforms and DNA-PK. This tool compound has been utilized in preclinical research to investigate mTOR signaling in cancer models, both in vitro and in vivo, during its Phase 1 clinical development.

Product Specifications

CAS Number

936890-98-1

Product Name Alternative

DNA-PK, DNAPK, ASP 4786, ASP 7486, ASP-4786, ASP7486, ASP-7486, ASP4786, Autophagy, OSI 027, OSI027, OSI-027, mTOR, mTORC2, mTORC1, inhibit, Inhibitor, Mammalian target of Rapamycin, PI3Kγ

Field of Research

Cell Biology, Molecular Biology, Signal Transduction

Purity

≥95% (May vary between batches)

Solubility

Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:15 mg/mL (36.91 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.92 mM)