PF 477736
PF-00477736 is a potent and selective ATP-competitive inhibitor of Chk1 (Ki=0.49 nM) with additional activity against kinases including Aurora-A and FGFR3. It is widely used in vitro and in vivo to study DNA damage response, cell cycle checkpoint control, and as a chemosensitizing agent in cancer research.
Product Specifications
CAS Number
952021-60-2
Product Name Alternative
FLT3, FGFR, cFms, c-Fms, Checkpoint Kinase (Chk), Chk1, Chk2, CDK, cRET, Aurora Kinase, AuroraKinase, VEGFR, VEGFR2, PF-736, PF 00477736, PF-736, PF00477736, PF477736, PF-477736, PF00477736, PF-00477736, PF 477736, PF 00477736, Src, Yes, RET
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
97.58% (May vary between batches)
Solubility
DMSO:50 mg/mL (119.2 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.77 mM)
Smiles
Cn1cc (cn1) -c1[nH]c2cc (NC (=O) [C@H] (N) C3CCCCC3) cc3c2c1cn[nH]c3=O
Molecular Formula
C22H25N7O2
Molecular Weight
419.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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