NVP-ADW742
NVP-ADW742 (ADW) is a potent and selective small molecule inhibitor of IGF-1R (IC50 = 0.17 μM), exhibiting over 16-fold selectivity versus the closely related InsR. It has been utilized in research to study IGF-1R signaling in cancer models, demonstrating antitumor activity in vitro and in vivo studies.
Product Specifications
CAS Number
475488-23-4
Product Name Alternative
Proapoptotic, solid, ADW, ADW 742, ADW742, ADW-742, Apoptosis, InsR, Insulin Receptor, IGF-1R, IGF1R, hematologic, multiple, myeloma, NVP ADW742, NVP-ADW 742, NVPADW742, NVP-ADW742, NVP-ADW-742, pleiotropic
Field of Research
Cell Biology, Signal Transduction
Purity
96.14% (May vary between batches)
Solubility
DMSO:10 mg/mL (22.05 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+90% Corn Oil:1 mg/mL (2.2 mM) ; Ethanol:3 mg/mL (6.61 mM)
Smiles
Nc1ncnc2n (cc (-c3cccc (OCc4ccccc4) c3) c12) C1CC (CN2CCCC2) C1
Molecular Formula
C28H31N5O
Molecular Weight
453.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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