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ZM39923 hydrochloride

ZM39923 hydrochloride is a selective JAK1 and JAK3 inhibitor with pIC50 values of 4.4 and 7.1, respectively, exhibiting minimal activity against JAK2 and moderate potency toward EGFR. This compound has been utilized in vitro to investigate JAK/STAT signaling pathways in immunology and oncology research, and it is also noted as a substrate for transglutaminase.

Product Specifications

CAS Number

1021868-92-7

Product Name Alternative

Inhibit, JAK1, JAK, Janus kinase, JAK3 Inhibitor IV, JAK3, EGFR, Inhibitor, ZM 39923, ZM 39923 HCl, ZM 39923 Hydrochloride, TGM2, ZM39923, ZM-39923, ZM39923 hydrochloride, ZM39923 Hydrochloride, ZM-39923 hydrochloride, ZM-39923 Hydrochloride

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.05% (May vary between batches)

Solubility

DMSO:28 mg/mL (76.11 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM) ; Ethanol:8 mg/mL (21.74 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

Cl.CC (C) N (CCC (=O) C1=CC=C2C=CC=CC2=C1) CC1=CC=CC=C1

Molecular Formula

C23H25NO·HCl

Molecular Weight

367.91

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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