Cyclopamine
Cyclopamine is a steroidal jerveratrum alkaloid that acts as a Smoothened (Smo) antagonist, with an IC50 of 46 nM in TM3Hh12 cells. It is a critical research tool for studying the Hedgehog signaling pathway in both in vitro and in vivo models of development and cancer.
Product Specifications
CAS Number
4449-51-8
Product Name Alternative
11-deoxojervine
Field of Research
Cancer Biology, Cell Biology, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Hedgehog signaling pathway inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 4 mg/ml) or in Ethanol (up to 20 mg/ml)
Smiles
[H][C@@]12CC3O[C@]4 ([H]) C[C@H] (C) CN[C@@]4 ([H]) [C@@H] (C) [C@@]3 ([H]) C (C) =C1C[C@@]1 ([H]) [C@@]2 ([H]) CC=C2C[C@@H] (O) CC[C@]12C
Molecular Formula
C27H41NO2
Molecular Weight
411.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
Phytochemical extracted from Veratrum californicum
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