PHPS1
PHPS1 is a potent and selective Shp2 inhibitor that suppresses the oncogenic Shp2-E76K mutant-driven Erk1/2 activation. It effectively inhibits the anchorage-independent proliferation of various human cancer cell lines in vitro, making it a valuable chemical probe for studying Shp2 signaling in oncology research.
Product Specifications
CAS Number
314291-83-3
Product Name Alternative
Inhibit, kidney, lung, Erk1/2, Inhibitor, colon, cancer, carcinoma, atherosclerosis, Shp-1, SHP-2, Shp2, Shp1, Phosphatase, PHPS 1, PHPS1, PHPS-1, prostate, PTP1B
Field of Research
Metabolism Research
Purity
99.08% (May vary between batches)
Solubility
DMSO:16.25 mg/mL (34.91 mM)
Smiles
OS (=O) (=O) c1ccc (N\N=C2/C (=O) N (N=C2c2ccc (cc2) [N+] ([O-]) =O) c2ccccc2) cc1
Molecular Formula
C21H15N5O6S
Molecular Weight
465.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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