SCH900776 (S-isomer)
SCH900776 S-isomer (MK-8776 S-isomer) is a potent, selective, and orally active Chk1 inhibitor with an IC50 of 3 nM, showing weaker activity against Chk2 and CDK2. It is widely used in cancer research to study DNA damage response and has demonstrated chemosensitizing effects in various preclinical in vitro and in vivo models.
Product Specifications
CAS Number
891494-64-7
Product Name Alternative
CDK2, Chk1, Chk2, Inhibitor, MK-8776 S-isomer, inhibit, SCH900776, SCH-900776, SCH900776 (S isomer), SCH900776 (Sisomer), SCH-900776 (S-isomer), SCH900776 (S-isomer), SCH900776 S-isomer, SCH 900776, S-isomer
Field of Research
Cell Biology
Purity
98.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.63 mM) ; DMSO:100 mg/mL (265.78 mM)
Smiles
Cn1cc (cn1) -c1cnn2c (N) c (Br) c (nc12) [C@H]1CCCNC1
Molecular Formula
C15H18BrN7
Molecular Weight
376.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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