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SCH900776 (S-isomer)

SCH900776 S-isomer (MK-8776 S-isomer) is a potent, selective, and orally active Chk1 inhibitor with an IC50 of 3 nM, showing weaker activity against Chk2 and CDK2. It is widely used in cancer research to study DNA damage response and has demonstrated chemosensitizing effects in various preclinical in vitro and in vivo models.

Product Specifications

CAS Number

891494-64-7

Product Name Alternative

CDK2, Chk1, Chk2, Inhibitor, MK-8776 S-isomer, inhibit, SCH900776, SCH-900776, SCH900776 (S isomer), SCH900776 (Sisomer), SCH-900776 (S-isomer), SCH900776 (S-isomer), SCH900776 S-isomer, SCH 900776, S-isomer

Field of Research

Cell Biology

Purity

98.69% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.63 mM) ; DMSO:100 mg/mL (265.78 mM)

Smiles

Cn1cc (cn1) -c1cnn2c (N) c (Br) c (nc12) [C@H]1CCCNC1

Molecular Formula

C15H18BrN7

Molecular Weight

376.25

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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